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the maximum recommended daily oral dose is significantly lower than the maximum daily parenteral dose (2,3)

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However, while the preclinical data have frequently shown encouraging results, therapeutic cancer vaccines clinical trials, including those based on peptides have not provided satisfactory data to date

Metformin (Glucophage) belongs to a class of oral diabetes medication called biguanides biguanides are antihyperglycemic drugs that prevent the production of glucose in the liver, improving the bodys sensitivity to insulin and reducing the amount of sugar absorbed by the intestines

The half-life of a drug can be determined using the following equation: t 1/2 = (0.7 times V d ) / Cl Therefore, t 1/2 = (0.7 times 40L) / 2.0 L/hour, and t 1/2 = 14 hours